Gonzalez hits 3 homers as Rockies rout Astros 13-5

DENVER (AP) ? Carlos Gonzalez's swing appears effortless. The results have been smashing.

Gonzalez extended a power surge by hitting three home runs in his last three at-bats, Michael Cuddyer belted a grand slam and Dexter Fowler also homered, leading the Colorado Rockies past the Houston Astros 13-5 on Wednesday night for their third win in a row.

"All I've been doing is trying to put good swings on the ball," Gonzalez said. "Obviously, I'm not looking for a home run. I'm just looking to hit the ball hard and just make sure it's in the strike zone. I saw three around the strike zone and put a good swing on them. Home runs just happen. I think special nights are just meant to be."

He's been awfully special at the plate lately, going 10 for 16 with five home runs, seven RBIs and six runs scored in his last four games. He has 13 homers on the season.

"His focus at the plate right now, his plate discipline, is as good as I've ever seen it," Rockies manager Jim Tracy said. "He's stepping to another level, that's how dangerous he is."

The game was not without some concern for the Rockies, however. Star shortstop Troy Tulowitzki left the game in the top of the seventh with what the team said was a strained left groin. Tulowitzki appeared a little gimpy as he returned to the dugout after running out an infield groundout in the bottom of the sixth.

"We don't know anything more than just that. We just have to wait and see to what extent," Tracy said of the injury to Tulowitzki, who was scheduled to be re-evaluated on Thursday.

Gonzalez said he just wants to see Tulowitzki get healthy as soon as he can.

"I just want him to be healthy and get right and we all believe he's going to be even better," Gonzalez said. "He's showing signs that he's going to contribute a lot to this team, and I know he's going to do a lot of damage and help the team when he gets back."

Gonzalez did much of the damage against the Astros, breaking a 5-5 tie with a solo shot leading off the fifth off Lucas Harrell (4-4).

"He is a good hitter. If you leave something out over the plate, he's going to hit it hard," Harrell said.

Gonzalez added a two-run drive off reliever Xavier Cedeno as part of a six-run sixth and then had another solo shot, driving the first offering from David Carpenter into the right field seats in the bottom of the eighth inning.

It was Gonzalez's first career three-homer game. He has had four multihomer games this season and eight in his career.

Cuddyer connected in the first inning on the first pitch he saw from Harrell for his seventh career slam and second this season, but it had to survive a replay review by the umpires after a fan reached over the right field railing to catch the ball. The replay showed the ball had cleared the yellow boundary marker atop the right field scoreboard before being caught.

Fowler, who had a game-ending RBI triple among his team record-tying seven hits in Monday's doubleheader sweep of Houston, doubled and scored in the second inning and had a three-run homer off reliever Rhiner Cruz in the sixth for his career-high eighth home run of the season.

"The home runs were the difference," Astros manager Brad Mills said. "Five home runs with the first being a grand slam. We battled back and had a lot of hits. But they won it. They got the five homers."

Harrell, who outdueled the Dodgers' Clayton Kershaw in a 3-1 victory last time out, gave up a career-high nine runs on 10 hits in five innings. He struck out four and walked three.

Christian Friedrich (3-1) allowed five runs on 11 hits in six innings, shaking off a rough third inning in which the Astros scored four runs.

Chris Snyder had a two-run double, Chris Johnson had a sacrifice fly and Justin Maxwell added an RBI single as the Astros pulled into a 5-5 tie. But Houston couldn't sustain the momentum, losing its fifth in a row and its sixth straight to the Rockies at Coors Field.

The Rockies' run total was the highest allowed by the Astros this season, surpassing the previous high of nine, which the Astros had done twice this season, most recently in a 9-7 loss to Colorado in the opener of Monday's doubleheader.

NOTES: Prior to the game, the Rockies designated LHP Jamie Moyer for assignment and recalled pitcher Carlos Torres from Triple-A Colorado Springs. The Rockies have 10 days to trade or release the 49-year-old Moyer, who became the oldest pitcher to win as a starter when he beat the San Diego Padres on April 17. ... The Astros send RHP Bud Norris (5-1) against Colorado's Jeremy Guthrie (2-3) in Thursday's finale of the four-game series. Norris has gone 4-0 with a major-league low 1.17 ERA in five previous starts during May. ... Cuddyer has two of the Rockies' four grand slams this season. He hit his first on May 5 against Atlanta.

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Sony's Next Generation Game Console To Still Have An Optical Disc ...

Sony has reporteddly rejected a download-only plan for its next videogame console, opting to include an optical disk drive, the Wall Street Journal reported today citing people familiar with the matter.

Although online networks play an importand role in the videogame industry, Sony will keep the optical disk drive in its next game console, while back there was a rumor going around saying the "PS4" would be a fully digital system with no support for physical media. The reason? A download-only model would not be succesfull as Internet connections are too inconsistent around the world, the WSJ added.

Sony is planning a 2013 release for the successor to its PlayStation 3 console, people familiar with the matter said.

The company is also expected to change some components of the upcoming console, such as the graphics chips, which will reportedly made by AMD, ending a long-running partnership with Nvidia. Sony's current PS3 machine is running on IBM/Toshiba Cell processor.

Microsoft is also planning to include an optical disk drive in the successor to its Xbox 360 console.

Both Sony's and Microsoft's people declined to comment.

New consoles are expected to be hot topic at the E3 videogame exposition in Los Angeles next week, though the only formal announcement expected is a successor for Nintendo 's Wii, the new Wii U.

Last year, Nintendo showacsed tech demos, This year the Japanese company will showcase actual games running on the new console. A post on the official Wii U Facebook page was just published, stating, "Guess what the initial game releases will be for Nintendo's new home console, Wii U? Soon we'll scratch off to reveal the names!"

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Some points why you have to consider choosing an android cell ...

Android a favorite cellular system is the most favored decision of cellular phone amongst customers at this time. The Android as a Smartphone has in fact gained high-quality attractiveness inside of a limited period of time of time. The Android Smartphone is an unit which can help men and women multi activity with the most current Google Applications. Just one can evidently state that this telephone is just past sensible considering it would make its users activity convenient. Owning a Smartphone on your own is not ample right now with quite a lot of thefts happening. Like how every device requires protection, Android telephones much too involve safety so that they continue being harmless. In this page we would pretty much chat about three ways to get for Android Smartphone security.

Federal government is getting lots of attempts by introducing new Applications for Android phone security. For that reason, securing the up-to-date era Android mobile phone is not at all a subject to stress. Every single cellular phone requires a protection considering that it incorporates confidential info which have to not be uncovered to strangers. When it will come to securing your Android phone there are three necessary simple steps which you ought to maintain in mind.

&bullFirstly you will need to discontinue all actual physical accessibility to the telephone. If an individual tends to see your dropped telephone then you would surely not want him or her to swap on your mobile phone and achieve accessibility to all its facts. There are some telephones which consist of dual authentication applications which are easy to add many others. If you endeavor to configure the mobile cellphone for deleting all the material, upon a number of failed attempts you are all set with your check box. A good deal of Android telephones lock instantly if its not used for some time. This ultimately keeps your mobile secured.

&bullSecond essential stage which you need to have to sustain in thoughts is irrespective of whether the make any difference of the telephone is safe and sound and safe. Android phones presently consist of security protocols which a consumer can established up for securing his or her cellphone. All the subject is then deleted and erased from the telephone if the phone does not link to its home community. Also the user can pretty properly encrypt the info to 265 which is especially good for a classified info

&bullLast but not the minimum consumer can freely add priority protocols like HAIPE (High Assurance Online world Protocol Encrypt) considering that the NSA demands accessibility to all governments labeled protected IP router.

In the higher than pointed out two methods Android services code is required whereas in the very last step it is not needed as it will help in securing the communications going from the Android phone. Only for the goal of securing Android Smartphone Google had to come under a partnership and create Safe Android Kernel. The Secure Kernel is specially designed in a way that it allows in blocking communication going out from the cellphone in situation of some security violation.

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Facebook has its eyes on Face.com, reports say

By msnbc.com staff

There's nothing like an acquisition to?distract investors?from your falling stock price.?

Reports in the tech press Tuesday said that Facebook, whose stock is still reeling from the aftershocks of a bungled IPO, is looking to acquire Israel-based face recognition technology company Face.com for around $80 million to $100 million.

The Los Angeles Times reported that rumors of the deal for the startup surfaced in the Israeli press and then were quickly picked up by tech reporters. Several of the reports said that when they contacted Face.com CEO Gil Hirsch, he responded by saying he had no news to share.

Shares of Facebook (FB) were down about 7 percent on Tuesday to just below $30 on a day when most market indices were higher. It was the first time since Facebook's debut on May 18?that its shares dipped below $30,?putting the shares about?21 percent below the IPO price of?$38 a share.?It was also the first time that Facebook?options began trading.?

Facebook options began trading today on a bearish note. What does this indicate about the stock's future? The FMHR traders weigh in with the play.

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Pacific Coast Commercial | Property Management 101

May 29, 2012

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Property management can be defined as the leasing, managing, marketing and maintaining of real estate property that is owned by another party.

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Most often times in the property management industry these responsibilities are handled by a certified San Diego commercial property management company. Property management companies work to facilitate the relationship between property managers, property owners, and tenants to ensure that all aspects of managing, leasing, and maintaining a property are covered.

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Property owners are the primary benefactors of the services of commercial property management in San Diego. The property owner benefits by being alleviated from the stress that can be brought on by the complexities of playing landlord in a full time capacity. Most seasoned landlords have learned through experience that property management is a time consuming task that is more complex than merely insuring, listing and periodically maintaining a rental property.

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In most property management cases, a landlord need be fluent in handling the legalities tied to renting and leasing a real estate property, have the wherewithal to list, screen, and approve tenant rental applications, and be available 24/7 to any tenant demands or property issues so that they may be dealt with accordingly. When a property owner neither has the time nor the skills to become a full time landlord, the property owner turns the responsibility of property management over to a professional property management company to handle the intricacies of property management on their behalf to ensure that the tenants and the property are well taken care of.

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Of course property management companies don?t manage commercial property in San Diego out of the goodness of their hearts, but do so in exchange for a reasonable fee that is deducted from the overall rent. That fee goes to cover the services that a property management company provides to a property owner. One of the most important of those services is making sure that the rental property does not sit vacant but that it is always occupied by qualified tenants. Because the amount of compensation that a property management company can draw upon is tied directly to the rent that is being received, the best interest of the property management company is aligned naturally to that of a property owner, making it a focal point for both to ensure that the property is generating sufficient cash flows from happy tenants that are occupying the dwelling at all times.

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As a result, property management companies have developed rigorous screening processes for all potential tenants that include at the very least a background check, a credit check, and an evaluation of the tenant?s rental history. A good San Diego commercial property managementcompany will have a thorough evaluation process in place for any and all tenants that desire to rent property and will make it a priority to protect the property owner from unqualified tenants that are unfit to pay their monthly rental obligation.

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In addition to screening tenants and ensuring that the property is occupied, a property management company will also handle all legal documentation that is required to comply with government regulations and the Fair Housing Act. Companies offering commercial property management in San Diego deliver added value by assessing the current rental marketplace to make sure that a fair rent value is being placed on the property, take over responsibility of maintenance and repair, handle any inspections that may need to take place on site, enforce rent collection from tenants, and take responsibility over all advertising and marketing that is required to attract and retain tenants.

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Source: Property Management?Direct

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Verizon doubles FiOS speeds to 300Mbps, thumb-twiddling waits are officially over

Verizon's IP network traffic jam apparently wasn't that much of an issue, since it just kicked up the speeds for FiOS service by a notch... or ten. Unless you're a spendthrift sticking to the base 15Mbps plan, download speeds have more than doubled across the board -- including to an eye-watering 300Mbps if you opt for the costliest plan. Upload speeds aren't advancing quite so quickly, although those who spring for the two highest tiers will see their upload speeds crack 65Mbps. The fiber speed-up is being attributed to a flood of Internet video and cloud backups, both of which get downright reasonable at 300Mbps; Verizon figures that both a 2-hour HD movie download and a 10GB backup will finish in 22 minutes or less. Whether or not pricing will have changed will have to wait until the speed upgrades take effect in June. Somehow, we can't imagine a drop anytime soon in the $200 monthly outlay for the top tier.

Verizon doubles FiOS speeds to 300Mbps, thumb-twiddling waits are officially over originally appeared on Engadget on Wed, 30 May 2012 11:17:00 EDT. Please see our terms for use of feeds.

Permalink   |  FiOS Internet, Speed Fact Sheet (PDF)  | Email this | Comments

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5 Key Elements of a Successful Home Based Business | MLM ...

Posted on 29. May, 2012 by Athar in MLM Business

Who wouldn?t want to work from home? You can make your own hours, forget ever having to commute, and never have to answer to a boss. Plus, as a home based business owner, you have the potential to earn exponentially more than you ever will by punching a time clock.

Yet, there are so many home based business opportunities available that it?s often difficult to choose the one that is a good fit for you and that has the income potential that you need. To help you make your choice, here are five key elements to look for in a home based business.

1. Go with Network Marketing

While it?s true that not everyone succeeds at network marketing, the principles behind it are sound. After all, network marketing is essentially using and selling products through word of mouth. This approach allows you to reach out to an ever-growing number of people and reap the financial rewards of building your own downline. Because network marketing cuts out the middleman, your earning potential increases. In the process, you create the potential for residual income while enjoying low overhead and the opportunity to work when and where you want. Furthermore, when you take advantage of Internet-based network marketing, you are not bound by geographic boundaries; your customers and downline can reach global proportions.

2. Choose a Company that Offers Multiple Products

Every day, you use dozens of products. Some home based business opportunities focus on one product, while others focus on many. When you do the math, it?s easy to see why it?s preferable to choose a company that allows you to become a member and have access to a wide variety of products, as well as to sell those products.

3. Find Cutting Edge Products to Use and Sell

Few people need more candles, kitchenware, or knick-knacks. What they really need and want are information and mobile technology products, such as DSL, VOIP, and broadband. Baby boomers in particular are looking for values in discount shopping, travel, and professional services such as legal services and health services. Companies and entrepreneurs are always on the lookout for cutting edge business software, conference calling, SEO services, marketing products, and video production services.

4. Look for a Solid Compensation Plan

Compensation plans vary from company to company, so be sure to find one that gives you the greatest earning potential. A single paid matrix is an excellent approach, as is a 3 x 9 monthly matrix commission.

5. Gain Access to Business Building Tools

One of the premises of network marketing is that you don?t need to reinvent the wheel; the infrastructure for a successful business model already exists. When reviewing home based business opportunities, especially those that are Internet based, find one that allows you to grow your business through duplication, so that you can immediately get up and running. The company you work with should also have a support system that includes mechanisms to capture leads, create ads, and develop solid marketing strategies. Moreover, there should be a sense of community, camaraderie, and mutual support.

Launching your own home based business can not only lead you to a debt free life, but can also enable you to travel the path of true financial freedom.

Athar

"This is a guest post provided by some of our readers... If you would like to be part of our team visit our Jobs page. The articles written by Matt Lloyd can be found here -> Matt Lloyd "

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Hard Road Trio Headed for Central Texas

The Hard Road Trio took the long road to get to a place where their music feels at home. With their original Southwestern acoustic blend of Americana and Bluegrass music from the wide-open spaces of New Mexico, The Hard Road Trio -- mandolinist Steve Smith, guitarist/vocalist Chris Sanders and bassist Anne Luna -- is the amalgamation of three songwriters who have found their collective voice in the light and air of the Southwest.

The Hard Road Trio channeled their energy and captured their authentic sound on their new recording, Monticello. "We set up and recorded so much of this material live," says Smith. "It breathes." That live connection is captured in full force on their latest release. It has been hailed for its honesty and power by folk icon Tom Russell saying, "This fine CD reminds me of the raw and colorful beauty of the New Mexico landscape."

Together, The Trio writes crisp, soothing ("Best of Intentions") and personal ("Family Secrets") songs filled with clever melodies ("Honeymoon From..."), and throughout peaceful harmonies - music steeped in folk classicism that shows its live appeal in every telling verse. Monticello includes guest appearances by Michael Witcher, Nate Lee, Tim May, Bill Evans and co-producer James McLaughlin.

The album is Hard Road's fourth and the first to include bassist Luna, who has helped steer the group's path and bring their live energy into the studio. Luna also contributed the song "Break Free," which, with its slinky jazz bass line and breathy vocals, brings a darker edge to the disc. Come out to enjoy their show! (http://hardroadtrio.com)

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16-year-old sets off buzz over 325-year-old physics

Jugend Forscht

Sixteen-year-old Shouryya Ray, a student from Dresden who was born in Calcutta, submitted a paper proposing analytical solutions to two problems in particle dynamics.

By Alan Boyle

A research paper that claims to fill in a gap in Isaac Newton's formulas for the physics of falling objects has drawn worldwide attention to a 16-year-old student in Germany, but physicists are reserving judgment until they've seen the proof.

The focus of the buzz is Shouryya Ray, an Indian-born student who won second prize this month in the math and informatics category for Germany's Jugend Forscht student science competition. Ray tackled a couple of longstanding puzzlers for physics students: How do you account for air resistance in calculating the trajectory of ball thrown out at an angle? And precisely how does a ball thrown against the wall rebound?

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The first question relates to Newton's law of universal gravitation: In his Principia Mathematica, published in 1687, Newton laid out how a gravitational field would affect a thrown object ??but he didn't account for the effect of air resistance. Through the centuries, physicists have used numerical approximations to take drag into account, and when computers come into play, those approximations can be incredibly precise. But Ray said he wanted to come up with a set of formulas that could calculate the effect directly, even though his instructors said that had never been done.

"I asked myself: Why can't it work?" he told the German newspaper Die Welt.

That's what Ray tried to do in his prize-winning paper, titled "Analytical?Solution of Two?Fundamental?Unsolved?Problems of?Particle Dynamics" ("Analytische L?sung von zwei ungel?sten fundamentalen Partikeldynamikproblemen"). In addition to the falling-ball problem, Ray took on a puzzler of more recent vintage, having to do with the description of a particle's collision with a wall, as described by 19th-century theory. But it was the "kid-trumps-Newton" angle that really stirred up a buzz.

Die Welt's report came early in the game: The Daily Mail and?The Sunday Times of London picked up the story, adding to the sensation. The idea that a teenager could figure out something that Newton didn't is irresistible ? particularly when the teen is an immigrant from Calcutta who says he's no genius. But the story just sparked more questions among inquiring minds in such online hangouts as?Physics Forum,?Slashdot?and Reddit: What exactly did Ray do? And were these problems really such mysteries to solve?

That's a challenge, because Ray's paper was a school project submitted for a contest, and thus not subject to the publication process and peer review that professional work typically goes through. For that reason, the experts are reluctant to weigh in.

"This story seems rather suspicious," Richard Fitzpatrick, a physicist at the University of Texas in Austin, told me in an email. "None of the news reports give any details of the calculation. None of the people who hailed Shouryya Ray as a genius are scientists, and none of?them give the impression that they have seen the calculation in question. It is impossible to gauge the scientific merit of the calculation until it is made public."

Syracuse University physicist Simon Catterall said in an email that calculating the trajectories of falling objects hadn't been seen as a particularly grand puzzle of physics. "The background given in the article seems genuine enough, so it may indeed be true, but I haven't heard anything about a new solution to a Newtonian problem on the grapevine," he told me.

Based on what's come out about the work so far, the consensus seems to be that Ray has done amazing work for his age ? and if he had to choose between his passion for science and his passion for soccer, he'd be well-advised to pick math and physics.?His paper putting forth an "analytical solution to two fundamental unsolved problems" may not be the breakthrough that some of the reports have made it out to be, but that doesn't take anything away from the teenager's achievement.

"What Ray has worked out, almost certainly independently, would definitely put him in the 99th percentile amongst his peers and maybe even more," one Redditor observed.

By the way, the first-place winner in the math and informatics category, Julius Kunze, wrote a paper on relativistic ray tracing. But that's a different story...?

Update for 5 p.m. ET: Other experts on Newtonian physics have replied to my follow-up queries via email:

Oxford University physicist James Binney: "Doesn't sound too interesting to me. The resistance of air to the ball won't be susceptible to simple analytic formulae ??if the ball is of ordinary size, [greater than a centimeter] radius ??the flow around it will be in the high Reynolds-number regime and involve a thin boundary layer. Such flows were extensively studied from the last part of the 19th century, so it's true that they lie beyond Newton's knowledge. A good approximation will be to take the drag force as pi r^2 rho v^2, where r is the radius of the ball, v its speed and rho the density of air. I'm unaware of a puzzle regarding bouncing balls. In detail the bounce will depend on the physical properties of the ball ??as any squash player knows. Usually one adopts a coefficient of restitution.?To be impressed we need to know details."

University of Bristol physicist Michael Berry: "Without seeing the details of what Ray has claimed, it's impossible to comment intelligently. It depends crucially on how he has modeled the air resistance. But a falling body with air resistance (however modeled) is hardly a 'fundamental unsolved problem,' as he seems to think. There's a powerful aroma of hype."??

More about physics:

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Alan Boyle is msnbc.com's science editor. Connect with the?Cosmic Log?community by "liking" the log's?Facebook page, following?@b0yle on Twitter?or adding?Cosmic Log's Google+ page?to your circle. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for other worlds.

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It took Earth ten million years to recover from greatest mass extinction

ScienceDaily (May 27, 2012) ? It took some 10 million years for Earth to recover from the greatest mass extinction of all time, latest research has revealed.

Life was nearly wiped out 250 million years ago, with only 10 per cent of plants and animals surviving. It is currently much debated how life recovered from this cataclysm, whether quickly or slowly.

Recent evidence for a rapid bounce-back is evaluated in a new review article by Dr Zhong-Qiang Chen, from the China University of Geosciences in Wuhan, and Professor Michael Benton from the University of Bristol. They find that recovery from the crisis lasted some 10 million years, as explained May 27 in Nature Geoscience.

There were apparently two reasons for the delay, the sheer intensity of the crisis, and continuing grim conditions on Earth after the first wave of extinction.

The end-Permian crisis, by far the most dramatic biological crisis to affect life on Earth, was triggered by a number of physical environmental shocks -- global warming, acid rain, ocean acidification and ocean anoxia. These were enough to kill off 90 per cent of living things on land and in the sea.

Dr Chen said: "It is hard to imagine how so much of life could have been killed, but there is no doubt from some of the fantastic rock sections in China and elsewhere round the world that this was the biggest crisis ever faced by life."

Current research shows that the grim conditions continued in bursts for some five to six million years after the initial crisis, with repeated carbon and oxygen crises, warming and other ill effects.

Some groups of animals on the sea and land did recover quickly and began to rebuild their ecosystems, but they suffered further setbacks. Life had not really recovered in these early phases because permanent ecosystems were not established.

Professor Benton, Professor of Vertebrate Palaeontology at the University of Bristol, said: "Life seemed to be getting back to normal when another crisis hit and set it back again. The carbon crises were repeated many times, and then finally conditions became normal again after five million years or so."

Finally, after the environmental crises ceased to be so severe, more complex ecosystems emerged. In the sea, new groups, such as ancestral crabs and lobsters, as well as the first marine reptiles, came on the scene, and they formed the basis of future modern-style ecosystems.

Professor Benton added: "We often see mass extinctions as entirely negative but in this most devastating case, life did recover, after many millions of years, and new groups emerged. The event had re-set evolution. However, the causes of the killing -- global warming, acid rain, ocean acidification -- sound eerily familiar to us today. Perhaps we can learn something from these ancient events."

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Story Source:

The above story is reprinted from materials provided by University of Bristol.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Zhong-Qiang Chen, Michael J. Benton. The timing and pattern of biotic recovery following the end-Permian mass extinction. Nature Geoscience, 2012; DOI: 10.1038/ngeo1475

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

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A Guide to Basic Etiquette When Using a Chauffeur ... - Toronto Limo

Last updated 20 hours ago

Whether you are using a wedding limo, prom limousine services, or just getting a ride to the airport, proper etiquette will make the journey more enjoyable for everyone. Make the effort to be polite and personable to get the most out of your limo ride. Before you slide into the vehicle, brush up on your limousine etiquette to enhance your overall experience:

• Include a Tip
  A limo service combines a luxury vehicle with the highest quality customer service. Show your chauffeur your appreciation by including a tip with your ride. A fair tip is generally anywhere between 10% 15%. If you really enjoyed your experience, though, show your gratitude with a larger tip.
• Use Restraint When Drinking
  It is okay to enjoy some of the beverages provided in the limo, just try not to consume too much. Even though the chauffeur handles the driving for you, it is impolite to drink too much during the course of your limo ride. Take it easy when drinking so you and the driver can have an enjoyable evening.
• Do Not Overfill the Vehicle
  Whether you are traveling in a private or a corporate limo, it is important to avoid inviting too many passengers into your car. Overfilling the vehicle makes it more dangerous to drive. Do not put yourself, your fellow passengers, and your driver at risk of a traffic accident. Adhering to passenger suggestions will give you more space inside the limo and decrease your chances of getting into an accident.

Whether you need leisure or corporate limo services, 5 Star Limousine has Toronto?s transportation covered. It is our pleasure to bring you luxury vehicles and the best chauffeurs in the industry. We offer services for weddings, proms, business events, and all of your other transportation needs. For more information, visit us online or call (647) 955-7169.

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Never Take Your Eyes Off This Hacker Metric

If you?re like me, you?ve had enough of the Facebook IPO story. For tech entrepreneurs struggling to build stuff, the cacophony of recent press is just more noise. That?s why when my friend Andrew Chen posted an insightful analysis of Facebook user data, I was happy to get back to learning from what the company did right instead of debating what its bankers did wrong. Chen calculated Facebook?s historical ratio of daily active users (DAU) to monthly active users (MAU) and the stats are startling. Since March 2009, when the earliest data is available, approximately 50% of Facebook users logged in daily. As other technology companies struggle to maintain DAU to MAU ratios of 5% or less, Facebook?s numbers appear stratospherically high in comparison. But what is equally surprising is the consistency of that ratio over time. Despite periodic user revolts in reaction to changes in the site, the ratio remained strangely stable. In fact, the number has risen over the past year and is now hovering at 58% as of March of this year.

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An instrument to Help Mothers Obtain their Lives. | what is crm

Something to Help Mothers Get their Lives
Review of Orderly Days from Kate Conway as well as Motherhood Press
By Lisa M. Hendey

Typically by this time with the year, calendars and planners are discounted to half price and most moms have given up on yet another set connected with New Year?s resolutions, including the perennial favorite that you get their lives arranged. Thankfully, this year there can be a new tool out there that will help revolutionize the actual homes and spiritual lives of countless families.

The Orderly Days adviser, by Kate Conway in addition to Motherhood Press, provides a new perspective on time management. The first thing you?ll notice if you receive your Orderly Days planner is the small Rosary ring clipped to the within the three ring binder which has the planner. Conway?s introduction for your planner sets the tone for that tool, stating that her goal should be to provide a ?traditions day planner that makes it possible to organize your life how God intended ? in a very proper and orderly means. ?

The Orderly Days planner logo carries a gracefully drawn images, and uplifting fonts, artwork and scriptural referrals are sprinkled throughout. The planner is compact enough to match in a purse, diaper bag, or to sit neatly for your desk. The Personal Data again reinforces the focus on spirituality, by including important parish call and schedule information one of the other high priority items for example name, address and emergency contact lenses.

Kate Conway expresses the reason for helping women establish a ?God-focus? inside their lives, enabling all else to belong to place. She gently reminds us to show to Mary as a role model and intercessor, and lends an ecumenical spirit towards planner through her invites to women of additional faith traditions.

Proving that this planner has endurance, the calendar section consists of annual, moveable feasts and luxurious holidays through 2007. Other important features include a cross section of hopes, prayer request lists and also prayer prompts and a multitude of printed and internet religious reference guides. Each week features the ?weekly goals? worksheet that offers the user the chance to ponder and prioritize these areas: spiritual growth, home and family, development of spiritual presents, physical goals, ministry to others along with financial goals.

Countless other special features abound within the Orderly Days planner, but I would advocate it most highly to its emphasis on placing a top priority on building and maintaining a good relationship with God, and letting the important things about that friendship rule and enhance all the areas of our house and family life.

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Latest How To Invest In Canadian Stocks News - TSX Stocks : TSX ...

Canadian investors more optimistic than American neighbours
By Franklin Templeton Investments Corp. TORONTO, May 15, 2012 /CNW/ ? Canadians are decidedly more upbeat about the local economy and the investment climate than Americans, a poll by Franklin Templeton Investments has found. In its latest global survey ?
Read more on Sacramento Bee

3 Busy Energy Stocks
To that end, I've highlighted three energy stocks making smart moves to stay on top. Canadian midstream company Enbridge (NYSE: ENB.US) announced plans for numerous expansions across its system last week, including its Line 6B pipeline that connects ?
Read more on Motley Fool UK

Investing: Speculate on euro? Not a great idea
A somewhat milder, but still risky, play would be to invest in the currency of a country that's not in the eurozone and reasonably stable. CurrencyShares offers exchange-traded funds that invest in the Canadian dollar (FXC) or the Australian dollar ?
Read more on USA TODAY

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Quiet Revolution's old dreams fuel Quebec protests

MONTREAL (AP) ? Quebec's generous social services date back to sweeping reforms in the 1960s, a period of intense nationalism. Yet many Quebecers look back at the "Quiet Revolution" with regret over one unfulfilled promise: free higher education.

That sentiment is fueling Canada's most sustained student demonstrations ever. It has been anything but quiet.

Some 150,000 students in more than a dozen Quebec colleges and universities have been on strike since February to protest the provincial government's plan to raise tuition fees. Street protests in Montreal have ended in clashes with police and mass arrests.

A strict new law designed to stop the demonstrations has only broadened the movement to include separatists and Occupy protesters, and triggered a wider debate over public freedoms. The students are threatening to persevere through the summer, just when the city traditionally awakens from its dark and frigid winter for jazz and comedy festivals that draw in millions of dollars in tourist revenue.

The French-speaking province's average undergraduate tuition ? $2,519 a year ? is the lowest in Canada, and the proposed hike? $254 per year over seven years ? is tiny by U.S. standards. But opponents consider the raise an affront to the philosophy of the 1960s reforms that set Quebec apart not only from its U.S. neighbor but from the rest of Canada.

"The whole consensus around education was built around the Quiet Revolution," said Pierre Martin, a political science professor at the Universite de Montreal. "That consensus would tend toward a tuition-free model in the future. That was a promise."

As a result, he said, Quebecers don't compare their tuition rates to those in the U.S. or English-speaking Canada, but to those in European countries where higher education is free.

Quebec Premier Jean Charest, who has vowed to shake up the debt-ridden province's finances since he was elected nearly a decade ago, has refused to cave.

More than 2,500 students have been arrested since the demonstrations began more than 100 days ago, including nearly 700 this past Wednesday alone. The total is five times the arrests during a period in the 1970s when soldiers were deployed to the streets in Quebec because of a spate of terrorism by a group demanding independence from Canada.

The tuition hike is part of a broader effort to shift Quebec's fiscal burden away from taxpayers ? the province has some of the steepest personal income taxes in North America and the highest per-capita debt in Canada? and onto the shoulders of each person who uses a service.

"Every citizen has to do their part," Quebec Finance Minister Raymond Bachand told The Associated Press in a telephone interview. "This is the 21st century."

Bachand said the students want more money in their pocket to the detriment of others. He noted that the government has expanded student grants so that middle and lower income students can more easily afford the increase.

"We're talking about 50 cents a day so basically it's moved from a question of tuition fees to a question of a social movement like you've seen in other parts of the world," Bachand said. "We're not used to this as Canadians. We're used to sitting down, disagreeing, negotiating and coming to an agreement."

In an effort to restore peace, Charest's government passed emergency legislation on May 18 restricting protests and closing striking campuses until August. The law requires that police be informed eight hours before a protest begins, including details on the route of any demonstration of 50 or more people. It also prohibits demonstrations within 50 meters (165 feet) of a college and declares that anyone who incites or helps another person break the new protest regulations can be fined.?

The new law has "changed the discourse now and introduced a new element into the debate, and that is the question of rights," said Bruce Hicks, a political scientist at Concordia University. The students have challenged the law in court.

Provincial Public Safety Minister Robert Dutil said Quebec cities are simply joining others that already have tough rules for organizing protests, including Los Angeles and New York.

"Law 78" has inspired a particularly cacophonous form of protest: from 8 p.m. to 8:15 p.m., people around Quebec emerge onto sidewalks and balconies to bang pots and pans.

Anne Claude, a 23-year-old computer student banging pots with a friend one evening in the heart of Montreal's Latin Quarter, said the law has only increased her resolve to be heard.

"The new law limits our ability to demonstrate," Claude shouted over the noise.

Across the street, pizza parlor owner Naeem Ahmed shook his head when he recalled the sight of an open fire hydrant gushing water into his business and a bonfire lit dangerously close by.

Ahmed, 37, has had a front row seat to more than 30 straight nights of protests. Confrontations between helmeted police and students have scared customers away. Students sometimes seek shelter in his establishment to escape police sweeps.

"For businesses it has been really, really horrible," Ahmed said, taking a break with some of his employees to look at cellphone footage of a recent protest. One of his employees joined the pot-bangers, clanging two trash lids together.

"Police come and ask everybody to leave," he said.

Still, he sympathizes with the students. "If you go to any country, when the students hit the streets, you have to listen to them," he said. "When they come out you have to accept it."

The student groups and the government have announced their intention to return to negotiations in the next days, with Quebec Education Minister Michelle Courchesne saying she expects a "very, very important" session following positive discussions over the phone.

But the two sides seem far apart. Student leader Gabriel Nadeau-Dubois wants to propose a long-term plan that would essentially fulfill the promise of the Quiet Revolution: scrapping university tuition fees altogether within five years and funding that by increasing taxes on financial institutions.

That is the opposite of what the government wants.

"Sacred cows only exist in India," the finance minister has repeatedly said.

___

Gillies reported from Toronto.

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CBMBA 2012 Season Kick-off Party & Natty Trails Day Weekend!

Crested Butte Mountain Bike Association (CBMBA) will celebrate the official opening of CBMBA?s 30th Season with its Annual Meeting & Kick-Off party on Friday June 1st at Rainbow Park in CB. The Annual Meeting will run from 4:00PM to 6:00PM.

CBMBA members and the community-at-large will hear all about CBMBA?s exciting 2012 season of events; new community initiatives and legendary trail work days, as well as have an opportunity to provide input and ideas.

CBMBA?s Annual Party will immediately follow the meeting at 6:00PM. A chicken BBQ dinner will be provided to the first 100 participants. The BBQ will be supplied by Sally K. Johnson, and the beer will be provided by New Belgium. Prize raffles courtesy of Osprey, Kenda, Smith Optics, Clif, Mountain Khakis, Doc Brown, Acli-Mate, Peak Sports, and Primal!

Natty Trails Day: The trail work-day will begin Saturday June 2nd at 9:00AM at the Slate River Winter Trailhead, Land Trust Kikel Parcel. CBMBA encourages everyone to RIDE YOUR BIKE to the trailhead! If driving, please park on the County Road and respect natural lands on site. Shuttles from the 4-Way (Chamber Parking lot) will be at 8:30AM, 9:00AM, and 9:30AM, courtesy of Jim Schmidt and Alpine Express. An after work-day party will follow at 4:00PM at the Brick Oven, raffle prizes courtesy of: Osprey, Smith Optics, Clif, Mountain Khakis, Doc Brown, Kenda, Acli-Mate, Peak Sports, and Primal.

To celebrate its 30th year as ?The Oldest Mountain Bike Club in the World?, CBMBA, will give away a customized, CBMBA 30th Anniversary Electra Courier 3i Cruiser Bike. Any new membership or renewal is includes an automatic entry to the bike drawing!

CBMBA is also rolling out its new logo and merchandise this season including; bike jerseys, pint glasses, T-shirts, kids and dog wear.

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Self improvement Can Be Achieved With Subliminal Messages ...

Self improvement Can Be Achieved With Subliminal Messages

yadi - 24 May 2012, 05:05

There are a lot of applications on the industry that demand enormous investments of time and income, subliminal messaging does neither and will get you what you desire out of life.

Any selection you make to improve oneself begins with you and your enthusiasm to take that very first step and place it into action. A critical commitment is necessary for you to obtain that larger state of living you so want. Self improvement is easier than ever just before with subliminal audio.

Despite the fact that they are audio recordings that need to have to be played and heard, youre technically not necessary to genuinely need to have to concentrate and focus on something. What subliminal messaging will do is inspire mind and give solid foundations to your thought patterns helping you achieve your targets.

On prime of the uncomplicated strategy, any logical resistances your thoughts would generally place up are bypassed by the subconscious comprehension achieved by subliminal messaging. This will allow you to tackle the biggest difficulties in your personal life and make alterations that typical conscious self help applications are incapable of.

Mainly because you are sending facts into the subconscious thoughts you can stay clear of any logical mental resistances and make potent alterations from inside , modifications which genuinely will have a enormous influence on your patterns of thinking, oneself beliefs and your complete life.

There are a huge quantity of targeted subliminal tracks which will put you on the rapid track to developing to be the extremely prime person you can be. You can literally get a subliminal album for pretty much almost everything ? from weight loss to stopping smoking, enhancing self-confidence, growing memory, even to help you to achieve achievement with the subliminal law of attraction and substantially much more.

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Finding Your Voice | GeekGirlCon

Hey guys, Shubz here! Anyone on staff will tell you that when I?m in the room, you?re more than likely to hear me (and laugh). However, it wasn?t always the case. I never had a problem speaking out or speaking my mind, but it never seemed like it was for myself. You see, I usually am speaking on behalf of something, whether it be my job or my family. It wasn?t until a year ago that I discovered that I CAN have my own voice ? literally and figuratively.

Here's a re-enactment of how things went for me in ballet class.

Time travel back 20+ years, and you would have found me in a dance class, learning the delicate dance form known as ballet. While ballet became a gateway to other forms like jazz, contemporary, and (my favorite) hip-hop, I hid behind my choreography. I chose to use movement as a way for people to see and experience my view without ever having to say a thing. I loved it. Every kick and every step had a purpose and a meaning. I thought there was nothing else that I could use as a platform to fully express who I was.

This is where magic gets written. Behold the notebook!

Let?s warp speed it back to the near present; my body has succumbed to the wear and tear of an active childhood and early adulthood. I no longer am active as a dancer, and it left quite a void in my life that I didn?t have an outlet with which I could create. I found writing by chance, a dear friend involved in local theatre heard me rap Sir Mix-A-Lot?s ?Baby Got Back? and insisted I begin to write. Eventually, I meet my husband, Aaron, who introduced me to this genre of Nerdcore and a community, (NerdcoreNow), where others are producing music.

When Aaron and I are not rapping, we are practicing our gloriously awesome poses.

I wrote, I recorded, and I performed. While I was met by many who enjoyed my music, I had my setbacks. There were folks that dismissed women rapping and others that didn?t like what I had to rap about. However, I couldn?t quit. I have never been the person to throw in the towel ? not in dance, and certainly not in this art form that I had just begun to play with. My perseverance paid off. I was awarded with NerdcoreNow?s Best Newcomer Award for 2011, and I got the respect that I thought I wouldn?t get by just writing and speaking into a mic. The acknowledgement is something that I refuse to rest my laurels on; now I?m working on an album!

I always wonder what would have happened if I didn?t take up my friend?s encouragement to write. What would I end up doing for a creative outlet? WOULD I have one? What?s great is that I don?t have to answer those questions because I just got brave enough to stretch myself out to try something that I thought I would never do. Sure, I?ve only just begun, but if this is how my start has panned out, I can?t wait to experience the journey that lies ahead!

What do YOU consider to be your voice? Leave us a comment and let your creative flag fly!

-
Shubz K. Blalack
PR Content Producer
prcontent@geekgirlcon.com

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Group: S.Sudan troops kill, torture minority tribe

JUBA, South Sudan (AP) ? South Sudan military forces tasked with carrying out a disarmament campaign among feuding ethnic groups are raping, torturing and killing members of a minority community, community leaders and aid workers say.

The disarmament campaign follows two outbreaks of violence linked to cattle raids between the Murle and Lou Nuer tribes over the last year in the remote state of Jonglei. Hundreds ? and likely more than 1,000 ? people were killed in the two clashes.

In an effort to stem future violence, the Sudan People's Liberation Army, South Sudan's military, embarked on a disarmament campaign in March in which more than 10,000 weapons have been taken so far, said military spokesman Col. Philip Aguer.

But aid groups and community members say the SPLA is killing and torturing members of the Murle, a tribe reviled by many other South Sudanese, while carrying out the disarmament campaign. Alleged abuses include simulated drownings, tying up young men to trees and beating them, and widespread rape against women.

The Murle appear to be ostracized by most other tribes in South Sudan in part because they received military support from leaders in Khartoum, Sudan, when the south and north battled in a two-decade civil war. The Murle also have a reputation for carrying out child abductions from other tribes and of conducting cattle raids that can results in hundreds of human deaths and tens of thousands of stolen cattle.

Allegations of abuse during the disarmament campaign are being investigated by military lawyers, Aguer said.

A state government report dated March 30 and obtained by The Associated Press listed some of the deaths: James Kengen Logidang was killed at home while sitting in a chair. Korok Manyngar Kengen, 15, was killed as his cattle were being stolen by SPLA soldiers. "The boy didn't have a gun," the report said.

The aid group Medecins Sans Frontieres, or Doctors Without Borders, said it has treated 30 patients since mid-March who suffered injuries from the disarmament campaign. Two have since died. Three patients had gunshot wounds and 26 had trauma injuries from beatings, the group said.

Aid groups contend that such numbers are underreported because most of the attacks take place in remote areas.

The disarmament campaign began as a voluntary handing over of guns, and then was to move into a compulsory phase, though military leaders have since said the voluntary phase would continue. Aid groups question whether the process is truly voluntary.

Peter Guzulu, a member of the Murle community, said at least 10 people have been killed "for no apparent reason." An 11th death took place against a male running from soldiers with a rifle in hand, he said.

Guzulu was the chairman of the government-run Jonglei Human Rights Commission from September 2010 until mid-March, when he said he was dismissed by the governor but wasn't told why. Guzulu believes he was removed "so I didn't talk to journalists or write reports."

"People are being beat in the towns and villages. They are told to confess to having guns. Women are beaten. Some are raped. When is this torture going to end? That is the question people ask all the time," he said.

Aguer said all communities in Jonglei are being disarmed. He said the Murle have the most weapons and that some members are heading into Ethiopia to keep their AK-47 assault rifles.

A report published last month by five aid groups, including Washington D.C.-based Pact and the South Sudan Law Society, said the current disarmament campaign ? the fifth in Jonglei in the last six years ? risks perpetuating a cycle of violence that has seen thousands killed and hundreds of thousands displaced in recent years. If the Murle believe they are being forcibly targeted in the campaign, the report said, they will re-arm and seek revenge.

The report urges the U.N. to prioritize the protection of civilians.

A statement this month from the U.N.'s top representative in South Sudan, Hilde Johnson, commended the disarmament effort, but critics of the campaign say the U.N. mission in South Sudan is ignoring evidence of abuse and torture.

The U.N. said in April that a peaceful disarmament campaign that respects human rights is vital to ending the cyclical violence and noted that while cases of abuse and sexual violence have been reported they do not appear to be part of a systematic campaign.

Kouider Zerrouk, a spokesman for the U.N. mission, said the U.N. has no way of knowing how many cases of abuse have occurred.

"These human rights violations are serious and are a concern for us," Zerrouk said. "But if we look into the whole process covering the whole region as big as Bangladesh, yes, generally it went in a peaceful manner in the sense that there was no outbreak of major clashes between communities."

Aguer said the disarmament campaign would continue for the rest of the year.

Judy McCallum, the former head in South Sudan of the aid group Pact, said the Murle are "basically under siege" by the government and military. She added that Murle youth are "out of control" ? a reference to cattle-raiding attacks ? but have no path to improve their lives.

Aid groups, McCallum said, are reporting systemic rape and drownsings. "Everyone I talk to say women are being raped constantly. So there's no incentive to give up their guns," she said. She said there is impunity for violence against the Murle.

McCallum said the U.N. is overemphasizing the success of the disarmament campaign and does not appear to be adequately concerned with the protection of civilians.

Minority Rights Group International on Thursday released new rankings of peoples under threat. South Sudan ? which broke away from Sudan last year to become the world's newest nation ? ranked in the top 10 because of the Murle-Lou Nuer violence.

In December and January, members of the Lou Nuer community attacked the Murle, likely killing hundreds of people. That attack came in retaliation for an August attack by the Murle that killed at least 600.

Associated Press

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Northern California man finds giant oyster

EUREKA, Calif. (AP) ? A northern California man who's been searching for years for a record-sized oyster appears to have found one.

The Eureka Times-Standard reports (http://bit.ly/JAp102 ) Richard Mesce found the 13-inch-long, 6-inch-wide mollusk in the muddy bottom of Humboldt Bay. It's estimated at 80 years old.

The retired pilot took the oyster to a Humboldt State University oceanographer for an official measurement, a requirement of the Guinness World Records' application.

The current record-holding oyster measures 12 inches long and 5 ? inches wide.

Mesce started searching in 2006, when he happened upon a large oyster in the area. Paddling in his kayak, he continued his quest when the tide was right.

If the oyster is confirmed the largest, Humboldt State University has agreed to keep the mollusk in its aquarium, where it can continue to grow.

Associated Press

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Patients' skin cells turned into heart muscle cells to repair their damaged hearts

ScienceDaily (May 22, 2012) ? For the first time scientists have succeeded in taking skin cells from heart failure patients and reprogramming them to transform into healthy, new heart muscle cells that are capable of integrating with existing heart tissue.

The research, which is published online May 22 in the European Heart Journal, opens up the prospect of treating heart failure patients with their own, human-induced pluripotent stem cells (hiPSCs) to repair their damaged hearts. As the reprogrammed cells would be derived from the patients themselves, this could avoid the problem of the patients' immune systems rejecting the cells as "foreign." However, the researchers warn that there are a number of obstacles to overcome before it would be possible to use hiPSCs in humans in this way, and it could take at least five to ten years before clinical trials could start.

Recent advances in stem cell biology and tissue engineering have enabled researchers to consider ways of restoring and repairing damaged heart muscle with new cells, but a major problem has been the lack of good sources of human heart muscle cells and the problem of rejection by the immune system. Recent studies have shown that it is possible to derive hiPSCs from young and healthy people and that these are capable of transforming into heart cells. However, it has not been shown that hiPSCs could be obtained from elderly and diseased patients. In addition, until now researchers have not been able to show that heart cells created from hiPSCs could integrate with existing heart tissue.

Professor Lior Gepstein, Professor of Medicine (Cardiology) and Physiology at the Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Technion-Israel Institute of Technology and Rambam Medical Center in Haifa, Israel, who led the research, said: "What is new and exciting about our research is that we have shown that it's possible to take skin cells from an elderly patient with advanced heart failure and end up with his own beating cells in a laboratory dish that are healthy and young -- the equivalent to the stage of his heart cells when he was just born."

Ms Limor Zwi-Dantsis, who is a PhD student in the Sohnis Research Laboratory, Prof Gepstein and their colleagues took skin cells from two male heart failure patients (aged 51 and 61) and reprogrammed them by delivering three genes or "transcription factors" (Sox2, Klf4 and Oct4), followed by a small molecule called valproic acid, to the cell nucleus. Crucially, this reprogramming cocktail did not include a transcription factor called c-Myc, which has been used for creating stem cells but which is a known cancer-causing gene.

"One of the obstacles to using hiPSCs clinically in humans is the potential for the cells to develop out of control and become tumours," explained Prof Gepstein. "This potential risk may stem from several reasons, including the oncogenic factor c-Myc, and the random integration into the cell's DNA of the virus that is used to carry the transcription factors -- a process known as insertional oncogenesis."

The researchers also used an alternative strategy that involved a virus that delivered reprogramming information to the cell nucleus but which was capable of being removed afterwards so as to avoid insertional oncogenesis.

The resulting hiPSCs were able to differentiate to become heart muscle cells (cardiomyocytes) just as effectively as hiPSCs that had been developed from healthy, young volunteers who acted as controls for this study. Then the researchers were able to make the cardiomyocytes develop into heart muscle tissue, which they cultured together with pre-existing cardiac tissue. Within 24-48 hours the tissues were beating together. "The tissue was behaving like a tiny microscopic cardiac tissue composed of approximately 1000 cells in each beating area," said Prof Gepstein.

Finally, the new tissue was transplanted into healthy rat hearts and the researchers found that the grafted tissue started to establish connections with the cells in the host tissue.

"In this study we have shown for the first time that it's possible to establish hiPSCs from heart failure patients -- who represent the target patient population for future cell therapy strategies using these cells -- and coax them to differentiate into heart muscle cells that can integrate with host cardiac tissue," said Prof Gepstein.

"We hope that hiPSCs derived cardiomyocytes will not be rejected following transplantation into the same patients from which they were derived. Whether this will be the case or not is the focus of active investigation. One of the obstacles in dealing with this issue is that, at this stage, we can only transplant human cells into animal models and so we have to treat the animals with immunosuppressive drugs so the cells won't be rejected."

Much research has to be conducted before these results could be translated into treatment for heart failure patients in the clinic. "There are several obstacles to clinical translation," said Prof Gepstein. "These include: scaling up to derive a clinically relevant number of cells; developing transplantation strategies that will increase cell graft survival, maturation, integration and regenerative potential; developing safe procedures to eliminate the risks for causing cancer or problems with the heart's normal rhythm; further tests in animals; and large industry funding since it is likely to be a very expensive endeavour. I assume it will take at least five to ten years to clinical trials if one can overcome these problems."

Prof Gepstein and his colleagues will be carrying out further research into some of these areas, including evaluating using hiPSCs in cell therapy and tissue engineering strategies for repairing damaged hearts in various animal models, investigating inherited cardiac disorders, and drug development and testing.

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Story Source:

The above story is reprinted from materials provided by European Society of Cardiology (ESC), via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Limor Zwi-Dantsis, Irit Huber, Manhal Habib, Aaron Winterstern, Amira Gepstein, Gil Arbel, and Lior Gepstein. Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. European Heart Journal, May 22, 2012 DOI: 10.1093/eurheartj/ehs096

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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